despair (
http://definr.com/despair)
n 1: a state in which everything seems wrong and will turn out
badly; "they were rescued from despair at the last
minute" [syn:
desperation]
2: the feeling that everything is wrong and nothing will turn
out well [ant:
hope]
v : abandon hope; give up hope; lose heart; "Don't despair--help
is on the way!" [ant:
hope]