derangement (
http://definr.com/derangement)
n 1: a state of mental disturbance and disorientation [syn: {mental
unsoundness},
unbalance]
2: the act of disturbing the mind or body; "his carelessness
could have caused an ecological upset"; "she was
unprepared for this sudden overthrow of their normal way
of living" [syn:
upset,
overthrow]